Sulphamethoxazole prophylaxis in the otitis-prone child.

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Sulphamethoxazole prophylaxis in the otitis-prone child.

A bedtime dose of sulphamethoxazole was effective in preventing ear infections in otitis-prone young children. Thirty-three such children were studied by means of a random, double-blind, placebo-controlled, cross-over protocol. Nine (27%) of 33 children treated with sulphamethoxazole experienced 10 episodes of acute suppurative otitis media or otitis media with effusion while 19 (58%) of 33 chi...

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Differences in innate immune response gene regulation in the middle ear of children who are otitis prone and in those not otitis prone

OBJECTIVE Acute otitis media (AOM) causes an inflammatory response in the middle ear. We assessed differences in innate immune responses involved in bacterial defense at onset of AOM in children who were stringently defined as otitis prone (sOP) and children not otitis prone (NOP). STUDY DESIGN Innate immune genes analysis from middle ear fluid (MEF) samples of children. METHODS Genes of to...

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A child with recurrent acute otitis media.

Acute otitis media refers to inflammation of the middle ear of rapid onset presenting with local symptoms, the most common being earache and rubbing or tugging of the affected ear and systemic signs such as fever, irritability and poor sleep. Acute otitis media may be caused by viral or bacterial pathogens. The commonest viral pathogens are Respiratory Syncytial Virus, Adenovirus and Influenza ...

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Treatment of chancroid. A comparison of sulphamethoxazole and trimethoprim-sulphamethoxazole.

Since sulphonamides are no longer predictably effective in the treatment of chancroid the combination of trimethoprim-sulphamethoxazole (TMP-SMX) was evaluated to identify other effective regimens. One hundred and nine patients with genital ulcers (75 men and 34 women) seen at the Special Treatment Clinic in Nairobi, Kenya, were randomly assigned to treatment with a seven day course of either s...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1982

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.57.8.590